What is OA of the Knee?

Osteoarthritis (OA) is a common condition that causes joints to become stiff and painful. Millions of people have this condition1, so, if you have been diagnosed with it, you are not alone!

OA causes the smooth cartilage that covers and protects the ends of your bones to break down. In severe cases, your cartilage thins so much that your bones may begin to rub against each other. The lubricating ability of the natural fluid in your knee diminishes, and the cartilage no longer cushions the joint as well as it once did.1 This results in stiffness, swelling, and pain that can make walking difficult.

Your family history, age, weight and any knee injuries you may have had can all play a role in developing OA of the knee.

Signs and symptoms of osteoarthritis (OA) of the knee

If you have one or more of these symptoms in your knee, you may have OA:

  • Aches and pains, especially with motion
  • Stiffness, especially in the morning and when standing up
  • “Grating” or “catching” sensations
  • Limited motion
  • Swelling
  • For this and other information please see http://www.arthritis.org/

If you experience any of the above, talk to your health care provider.

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Important Safety Information

HYMOVIS® is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy or simple analgesics (e.g., acetaminophen).

HYMOVIS® is contraindicated in patients with known hypersensitivity (allergy) to hyaluronate preparations or gram-positive bacterial proteins. Do not administer HYMOVIS® to patients with infections or skin diseases in the area of the injection site or joint.

The safety and effectiveness of the use of HYMOVIS® have not been tested in pregnant women, nursing mothers, or children. The safety and effectiveness of the use of HYMOVIS® in joints other than the knee, or for use concomitantly with other intra-articular (IA) injections, have not been established. The effectiveness of repeat treatment cycles of HYMOVIS® has not been established.

Arthralgia, transient pain, or swelling may occur after the IA injection. The incidence of arthralgia in the clinical study for HYMOVIS® was equivalent to the control group. No serious adverse events or pseudoseptic reactions were reported. Transient increases in inflammation following any IA hyaluronan injection have been reported in some patients with inflammatory joint conditions.

Strict aseptic technique should be used by licensed medical professionals trained to deliver agents into the knee joint. Joint effusion should be removed prior to injection of HYMOVIS®. Do not use disinfectants containing quaternary ammonium salts for skin preparation as hyaluronan can precipitate in their presence.

Patients should avoid strenuous or prolonged (eg, more than one hour) physical activities within 48 hours following the IA injection.

Please see Prescribing Information.

Rx Only

HYMOVIS and HYADD 4 are registered trademarks of Fidia Farmaceutici S.p.A., Abano Terme, Italy. HYMOVIS® is manufactured by Fidia Farmaceutici S.p.A., Abano Terme, Italy. ©2017 Fidia Pharma USA Inc, Florham Park, NJ 07932